Tolerability and pharmacokinetics of oxaloacetate 100mg capsules in Alzheimer's subjects
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Tolerability and pharmacokinetics of oxaloacetate 100 mg capsules in Alzheimer's subjects
Bioenergetics and bioenergetic-related functions are altered in Alzheimer's disease (AD) subjects. These alterations represent therapeutic targets and provide an underlying rationale for modifying brain bioenergetics in AD-affected persons. Preclinical studies in cultured cells and mice found that administering oxaloacetate (OAA), a Krebs cycle and gluconeogenesis intermediate, enhanced bioener...
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Tolerability and Pharmacokinetics
Background and Purpose—UK-279,276, a recombinant glycoprotein, binds selectively to the CD11b/CD18 integrin on neutrophils and has the potential to modulate the neuroinflammation associated with acute stroke. After preclinical evidence of neuroprotection, UK-279,276 has entered clinical development. The purposes of this study were to evaluate the safety and tolerability of UK-279,276 and to exa...
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ژورنال
عنوان ژورنال: BBA Clinical
سال: 2016
ISSN: 2214-6474
DOI: 10.1016/j.bbacli.2016.03.005